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Article

The high-risk HPV16 E7 oncoprotein mediates interaction between the transcriptional coactivator CBP and the retinoblastoma protein pRb.

Journal of molecular biology - 12 Dec 2014

Jansma Ariane L, Martinez-Yamout Maria A, Liao Rong, Sun Peiqing, Dyson H Jane, Wright Peter E

Abstract excerpt

The oncoprotein E7 from human papillomavirus (HPV) strains that confer high cancer risk mediates cell transformation by deregulating host cellular processes and activating viral gene expression through recruitment of cellular proteins such as the retinoblastoma protein (pRb) and the cyclic-AMP response element binding binding protein (CBP) and its paralog p300. Here we show that the intrinsically disordered...

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Identifiers

PMID: 25451029
DOI: 10.1016/j.jmb.2014.10.021
PMCID: PMC4258470

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The high-risk HPV16 E7 oncoprotein mediates interaction between the transcriptional coactivator CBP and the retinoblastoma protein pRb.PMID 25451029Read ↗

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