Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular Determinants for the Inactivation of the Retinoblastoma Tumor Suppressor by the Viral Cyclin-dependent Kinase UL97.

The Journal of biological chemistry - 7 Aug 2015

Iwahori Satoko, Hakki Morgan, Chou Sunwen, Kalejta Robert F

Abstract excerpt

The retinoblastoma (Rb) tumor suppressor restricts cell cycle progression by repressing E2F-responsive transcription. Cellular cyclin-dependent kinase (CDK)-mediated Rb inactivation through phosphorylation disrupts Rb-E2F complexes, stimulating transcription. The human cytomegalovirus (HCMV) UL97 protein is a viral CDK (v-CDK) that phosphorylates Rb. Here we show that UL97 phosphorylates 11 of the 16 consensus...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus
Share to E2F1 Transcription Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Host-Pathogen Interactions

Share to Luciferases

Share to Phosphotransferases (Alcohol Group Acceptor)

Share to Primary Cell Culture

Share to Protein Interaction Domains and Motifs

Share to Retinoblastoma Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 26100623
DOI: 10.1074/jbc.M115.660043
PMCID: PMC4528131

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular Determinants for the Inactivation of the Retinoblastoma Tumor Suppressor by the Viral Cyclin-dependent Kinase UL97.PMID 26100623Read ↗

Human cytomegalovirus-encoded viral cyclin-dependent kinase (v-CDK) UL97 phosphorylates and inactivates the retinoblastoma protein-related p107 and p130 proteins.Semantic proximity Read ↗

Human papillomavirus 16 E7 inactivator of retinoblastoma family proteins complements human cytomegalovirus lacking UL97 protein kinaseSemantic proximity Read ↗

Cyclin-Dependent Kinase-Like Function Is Shared by the Beta- and Gamma- Subset of the Conserved Herpesvirus Protein KinasesSemantic proximity Read ↗

Phosphorylation of transcriptional regulators in the retinoblastoma protein pathway by UL97, the viral cyclin-dependent kinase encoded by human cytomegalovirusSemantic proximity Read ↗

Structural basis for tunable affinity and specificity of LxCxE-dependent protein interactions with the retinoblastoma protein familySemantic proximity Read ↗

Analysis of the structure-activity relationship of four herpesviral UL97 subfamily protein kinases reveals partial but not full functional conservation.Semantic proximity Read ↗

Conserved retinoblastoma protein-binding motif in human cytomegalovirus UL97 kinase minimally impacts viral replication but affects susceptibility to maribavir.Semantic proximity Read ↗

Conserved domains and structure prediction of human cytomegalovirus UL27 protein.Semantic proximity Read ↗

Amino acids of conserved kinase motifs of cytomegalovirus protein UL97 are essential for autophosphorylation.Semantic proximity Read ↗

Human Cytomegalovirus UL97 Phosphorylates the Viral Nuclear Egress ComplexSemantic proximity Read ↗

The many roles of the regulatory protein ICP27 during herpes simplex virus infectionSemantic proximity Read ↗

Three regions of the pRB pocket domain affect its inactivation by human papillomavirus E7 proteins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.