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Article

Role of LXCXE motif-dependent interactions in the activity of the retinoblastoma protein.

Oncogene - 27 Sept 2001

Chan H M, Smith L, La Thangue N B

Abstract excerpt

Cell cycle control by pRb requires the integrity of the pocket domain, which is a region necessary for interactions with a variety of proteins, including E2F and LXCXE-motif containing proteins. Through knowledge of the crystal structure of pRb we have prepared a panel of pRb mutant derivatives in which a cluster of lysine residues that demark the LXCXE peptide binding domain were systematically mutated. One of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11593423
DOI: 10.1038/sj.onc.1204793

Genes

HDAC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of LXCXE motif-dependent interactions in the activity of the retinoblastoma protein.PMID 11593423Read ↗

Mutagenesis of the pRB Pocket Reveals that Cell Cycle Arrest Functions Are Separable from Binding to Viral OncoproteinsSemantic proximity Read ↗

Structural basis for tunable affinity and specificity of LxCxE-dependent protein interactions with the retinoblastoma protein familySemantic proximity Read ↗

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The LxCxE pRb interaction domain of cyclin D1 is dispensable for murine development.Semantic proximity Read ↗

Dynamic site-specific recruitment of RBP2 by pocket protein p130 modulates H3K4 methylation on E2F-responsive promoters.Semantic proximity Read ↗

Mutation of the LXCXE binding cleft of pRb facilitates transformation by ras in vitro but does not promote tumorigenesis in vivo.Semantic proximity Read ↗

HPV 16E7 and 48E7 proteins use different mechanisms to target p130 to overcome cell cycle block.Semantic proximity Read ↗

HDAC5 Loss Impairs RB Repression of Pro-Oncogenic Genes and Confers CDK4/6 Inhibitor Resistance in CancerSemantic proximity Read ↗

Short linear motif core and flanking regions modulate retinoblastoma protein binding affinity and specificitySemantic proximity Read ↗

Conserved region 2 of adenovirus E1A has a function distinct from pRb binding required to prevent cell cycle arrest by p16INK4a or p27Kip1.Semantic proximity Read ↗

E2F and the molecular mechanisms of early cell-cycle control.Semantic proximity Read ↗

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