Article

3D Variability Analysis Reveals a Hidden Conformational Change Controlling Ammonia Transport in Human Asparagine Synthetase

2023-05-16

Abstract excerpt

<h4>ABSTRACT</h4> How motions in enzymes might be linked to catalytic function is of considerable general interest. Advances in X-ray crystallography and cryogenic electron microscopy (cryo-EM) offer the promise of elucidating functionally relevant conformational changes that are not easily studied by other biophysical methods. Here we use 3D variability analysis (3DVA) of the cryo-EM map for wild-type (WT) human...

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Literature Corpus work: 3fbc9618-342a-5081-8c04-7998b4be49fc
DOI: 10.1101/2023.05.16.541009

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3D Variability Analysis Reveals a Hidden Conformational Change Controlling Ammonia Transport in Human Asparagine SynthetaseDOI 10.1101/2023.05.16.541009Read

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