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Article

A new horizon in the phosphorylated sites of AGA: the structural impact of C163S mutation in aspartylglucosaminuria through molecular dynamics simulation.

Journal of biomolecular structure & dynamics - 1 May 2024

Balasundaram Ambritha, Ramireddy Sriroopreddy, S Udhaya Kumar, D Thirumal Kumar, Tayubi Iftikhar Aslam, Zayed Hatem, C George Priya Doss

Abstract excerpt

Aspartylglucosaminuria (AGU) is a lysosomal storage disorder caused by insufficient aspartylglucosaminidase (AGA) activity leading to chronic neurodegeneration. We utilized the PhosphoSitePlus tool to identify the AGA protein's phosphorylation sites. The phosphorylation was induced on the specific residue of the three-dimensional AGA protein, and the structural changes upon phosphorylation were studied via...

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PMID: 37334725
DOI: 10.1080/07391102.2023.2220798

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