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Article

Structure of human carbamoyl phosphate synthetase: deciphering the on/off switch of human ureagenesis.

Scientific reports - 23 Nov 2015

de Cima Sergio, Polo Luis M, Díez-Fernández Carmen, Martínez Ana I, Cervera Javier, Fita Ignacio, Rubio Vicente

Abstract excerpt

Human carbamoyl phosphate synthetase (CPS1), a 1500-residue multidomain enzyme, catalyzes the first step of ammonia detoxification to urea requiring N-acetyl-L-glutamate (NAG) as essential activator to prevent ammonia/amino acids depletion. Here we present the crystal structures of CPS1 in the absence and in the presence of NAG, clarifying the on/off-switching of the urea cycle by NAG. By binding at the...

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Identifiers

PMID: 26592762
DOI: 10.1038/srep16950
PMCID: PMC4655335

Genes

CPS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structure of human carbamoyl phosphate synthetase: deciphering the on/off switch of human ureagenesis.PMID 26592762Read ↗

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