Article

Cryo-EM reveals disrupted human p97 allosteric activation by disease mutations and inhibitor binding

2021-08-11

Abstract excerpt

<h4>ABSTRACT</h4> The human AAA ATPase p97, a potential cancer target, plays a vital role in clearing misfolded proteins. p97 dysfunction is also known to play a crucial role in several neurodegenerative disorders. Here, we present cryo-EM structural analyses of four disease mutants p97 R155H , p97 R191Q , p97 A232E , p97 D592N , as well as p97 E470D , implicated in resistance to the drug CB-5083. These stru...

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Literature Corpus work: e6d6aa6c-a45c-5411-8919-db39b9a3e0b1
DOI: 10.1101/2021.08.10.455711

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