Article

Critical Dynamics of Peripheral Immune Tolerance: A Treg-Tpex Antagonism Framework for Phase Transition and Immune State Stratification

2026-05-14

Abstract excerpt

<title>Abstract</title> <p>Paradigm shift: Peripheral immune tolerance is proposed here not as a static steady state but as a critical dynamical system, driven by the continuous accumulation of progenitor-exhausted T cells (Tpex). Under specific conditions, minor perturbations may trigger a nonlinear phase transition toward effector immunity. Core concept: This paper introduces a conceptual Tolerance Stability In...

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Literature Corpus work: f025d114-793e-54d5-97b6-ceef382e1aff
DOI: 10.21203/rs.3.rs-9648114/v1

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