Article
Resetting the immune system with immunoablation and autologous haematopoietic stem cell transplantation in autoimmune diseases.
Clinical and experimental rheumatology - 1 Jan 2000
Alexander Tobias, Arnold Renate, Hiepe Falk, Radbruch Andreas
Abstract excerpt
Over the past 20 years, immunoablation followed by transplantation of autologous haematopoietic stem cells (ASCT) has emerged as a promising treatment option for patients with severe forms of autoimmune diseases (ADs) that insufficiently respond to standard immunosuppressive or novel biologic treatment. Meanwhile, mechanistic studies have provided the proof-of-concept that the long-term, treatment-free remissions...
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