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The Cryptococcus neoformans STRIPAK complex controls genome stability, sexual development, and virulence

19 Nov 2024

Abstract excerpt

The eukaryotic serine/threonine protein phosphatase PP2A is a heterotrimeric enzyme composed of a scaffold A subunit, a regulatory B subunit, and a catalytic C subunit. Of the four known B subunits, the B"' subunit (known as striatin) interacts with the multi-protein striatin-interacting phosphatase and kinase (STRIPAK) complex. Orthologs of STRIPAK components were identified in Cryptococcus neoformans, namely...

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PMID: 39561188
DOI: 10.1371/journal.ppat.1012735

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