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<i>Salmonella</i> Effector SteE Reprogrammes the Macrophage Regulatory Network to Drive Specific Hyperactivation of STAT3 Target Genes

2025-07-14

Abstract excerpt

<h4>SUMMARY</h4> The ability of Salmonella Typhimurium to exploit macrophages as a niche for survival, replication and dissemination is central to its pathogenesis. The effector SteE, which polarises macrophages into an anti-inflammatory state, is critical during invasive disease. SteE operates via an unprecedented mechanism, reprogramming the host serine/threonine kinase GSK3 to perform tyrosyl-directed phospho...

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Identifiers and source

Literature Corpus work
3fa9991c-9e72-54d7-8883-1d2601650187
DOI
10.1101/2025.07.11.664171
Open publication

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<i>Salmonella</i> Effector SteE Reprogrammes the Macrophage Regulatory Network to Drive Specific Hyperactivation of STAT3 Target GenesDOI 10.1101/2025.07.11.664171
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