Back to search

Article

Fibrillin-Related Proteins Control Calcium Homeostasis in Dystrophic Muscle Across Species

2025-06-11

Abstract excerpt

Duchenne muscular dystrophy (DMD) involves progressive muscle degeneration associated with calcium dysregulation, but the mechanisms linking extracellular matrix (ECM) integrity to calcium homeostasis remain unclear. We investigated whether MUA- 3, a fibrillin-related ECM protein in Caenorhabditis elegans , contributes to calcium regulation in dystrophic muscle. Using fluorescent calcium imaging in transgenic wor...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
938cca57-bc7d-597e-804a-02b3fb0875dd
DOI
10.1101/2025.06.09.658655
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Fibrillin-Related Proteins Control Calcium Homeostasis in Dystrophic Muscle Across SpeciesDOI 10.1101/2025.06.09.658655
Muscular degeneration in the absence of dystrophin is a calcium-dependent process.Semantic proximity
Disrupted Calcium Homeostasis in Duchenne Muscular Dystrophy: A Common Mechanism behind Diverse ConsequencesSemantic proximity
Exercise exacerbates decline in the musculature of an animal model of Duchenne muscular dystrophySemantic proximity
Increased mitochondrial Ca <sup>2+</sup> contributes to health decline with age and Duchene muscular dystrophy in <i>C. elegans</i>Semantic proximity
Mechanotransduction coordinates extracellular matrix protein homeostasis promoting longevity in <i>C. elegans</i>Semantic proximity
DPY-17 and MUA-3 Interact for Connective Tissue-Like Tissue Integrity in Caenorhabditis elegans: A Model for Marfan Syndrome.Semantic proximity
InsP3R signaling mediates mitochondrial stress-induced longevity through actomyosin-dependent mitochondrial dynamicsSemantic proximity
Fibrillin Binds Calcium and Is Coded by cDNAs That Reveal a Multidomain Structure and Alternatively Spliced Exons at the 5′ EndSemantic proximity
The ALP-Enigma protein ALP-1 functions in actin filament organization to promote muscle structural integrity in Caenorhabditis elegans.Semantic proximity
Myoferlin Regulates Wnt/β-Catenin Signaling-Mediated Skeletal Muscle Development by Stabilizing Dishevelled-2 Against AutophagySemantic proximity
The integrin-adhesome is required to maintain muscle structure, mitochondrial ATP production, and movement forces in Caenorhabditis elegans.Semantic proximity
Form and function of actin impacts actin health and agingSemantic proximity
Select a neighboring publication to make it the new centre.