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Regulatory dissection of the severe COVID-19 risk locus introgressed by Neanderthals

27 Jan 2023

Abstract excerpt

Individuals infected with the SARS-CoV-2 virus present with a wide variety of symptoms ranging from asymptomatic to severe and even lethal outcomes. Past research has revealed a genetic haplotype on chromosome 3 that entered the human population via introgression from Neanderthals as the strongest genetic risk factor for the severe response to COVID-19. However, the specific variants along this introgressed...

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PMID: 36763080
DOI: 10.7554/elife.71235

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