Article

Human iPSCs from aged donors retain their mitochondrial aging signature

2024-04-19

Abstract excerpt

Aging represents the main risk factor for developing neurodegenerative disorders. One of the hallmarks of aging is mitochondrial dysfunction. Age-related mitochondrial alterations have been shown to affect mitochondrial energy metabolism and redox homeostasis as well as mitochondrial dynamics. In the present study, we addressed the question of whether or not, induced pluripotent stem cells (iPSCs) may be used as a...

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Literature Corpus work: 3f893420-bb30-50ef-9477-015f0289a1cd
DOI: 10.1101/2024.04.16.589733

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