Article

Preservation of an Aging-Associated Mitochondrial Signature in Advanced Human Neuronal Models

2024-03-31

Abstract excerpt

1. This study investigated whether induced pluripotent stem cell-derived neurons (iPSCsNs) and directly converted neurons (iNs) generated from the same cells of origin (human fibroblasts) represent aging-related characteristics on mitochondrial levels. There is still uncertainty regarding the potential for rejuvenation or preservation of an aging-associated donor signature in aged iPSCsNs upon transition through p...

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Literature Corpus work: 467d10b8-82eb-5556-b93f-520cfa5e18a0
DOI: 10.1101/2024.03.28.587193

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