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Article

Aged iPSCs display an uncommon mitochondrial appearance and fail to undergo in vitro neurogenesis.

Aging - 1 Dec 2014

Masotti Andrea, Celluzzi Antonella, Petrini Stefania, Bertini Enrico, Zanni Ginevra, Compagnucci Claudia

Abstract excerpt

Reprogramming of human fibroblasts into induced pluripotent stem cells (iPSCs) leads to mitochondrial rejuvenation, making iPSCs a candidate model to study the mitochondrial biology during stemness and differentiation. At present, it is generally accepted that iPSCs can be maintained and propagated indefinitely in culture, but no specific studies have addressed this issue. In our study, we investigated features...

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Share to Cellular Senescence
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Induced Pluripotent Stem Cells

Share to Membrane Potential, Mitochondrial

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Source

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Identifiers

PMID: 25567319
DOI: 10.18632/aging.100708
PMCID: PMC4298368

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