Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human iPSCs from Aged Donors Retain Their Mitochondrial Aging Signature

18 Oct 2024

Abstract excerpt

Aging represents the leading risk factor for developing neurodegenerative disorders. One of the nine hallmarks of aging is mitochondrial dysfunction. Age-related mitochondrial alterations have been shown to affect mitochondrial energy metabolism, reduction-oxidation homeostasis, and mitochondrial dynamics. Previous reports have shown that induced pluripotent stem cells (iPSCs) from aged donors do not keep the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue and Metabolism
Share to Anesthesia and Neurotoxicity Research
Share to Mitochondrial Function and Pathology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39456998
DOI: 10.3390/ijms252011199

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human iPSCs from Aged Donors Retain Their Mitochondrial Aging SignaturePMID 39456998Read ↗

Human iPSCs from aged donors retain their mitochondrial aging signatureSemantic proximity Read ↗

Aged iPSCs display an uncommon mitochondrial appearance and fail to undergo in vitro neurogenesis.Semantic proximity Read ↗

Preservation of an Aging-Associated Mitochondrial Signature in Advanced Human Neuronal ModelsSemantic proximity Read ↗

The Senescence-Related Mitochondrial/Oxidative Stress Pathway is Repressed in Human Induced Pluripotent Stem CellsSemantic proximity Read ↗

Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile.Semantic proximity Read ↗

The Mitochondrial Basis of Aging and Age-Related DisordersSemantic proximity Read ↗

Mitochondrial Contributions to Hematopoietic Stem Cell AgingSemantic proximity Read ↗

iPSCs, a Future Tool for Therapeutic Intervention in Mitochondrial Disorders: Pros and Cons.Semantic proximity Read ↗

Mitochondrial transfer from induced pluripotent stem cells rescues developmental potential of in vitro fertilized embryos from aging females†Semantic proximity Read ↗

Mitochondrial dysfunction in agingSemantic proximity Read ↗

The mitochondria regulation of stem cell aging.Semantic proximity Read ↗

The aging signature: a hallmark of induced pluripotent stem cells?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.