Article
Reanalysis of mtDNA mutations of human primordial germ cells (PGCs) reveals NUMT contamination and suggests that selection in PGCs may be positive.
Mitochondrion - 1 Jan 2024
Fleischmann Zoë, Cote-L'Heureux Auden, Franco Melissa, Oreshkov Sergey, Annis Sofia, Khrapko Mark, Aidlen Dylan, Popadin Konstantin, Woods Dori C, Tilly Jonathan L, Khrapko Konstantin
Abstract excerpt
The resilience of the mitochondrial genome (mtDNA) to a high mutational pressure depends, in part, on negative purifying selection in the germline. A paradigm in the field has been that such selection, at least in part, takes place in primordial germ cells (PGCs). Specifically, Floros et al. (Nature Cell Biology 20: 144-51) reported an increase in the synonymity of mtDNA mutations (a sign of purifying selection)...
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