Article

The need for high-quality oocyte mitochondria at extreme ploidy dictates germline development

2020-09-03

Abstract excerpt

<h4>ABSTRACT</h4> Selection against deleterious mitochondrial mutations is facilitated by germline processes, lowering the risk of genetic diseases. How selection works is disputed: experimental data are conflicting and previous modelling work has not clarified the issues. Here we develop computational and evolutionary models that compare the outcome of selection at the level of individuals, cells and mitochondri...

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Literature Corpus work: 683ace86-6bc9-5bf1-a18b-9b653ea1d077
DOI: 10.1101/2020.09.03.280628

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