Article

Population size interacts with reproductive longevity to shape the germline mutation rate

2023-12-08

Abstract excerpt

Mutation rates vary across the tree of life by many orders of magnitude, with lower mutation rates in species that reproduce quickly and maintain large effective population sizes. A compelling explanation for this trend is that large effective population sizes facilitate selection against weakly deleterious “mutator alleles” such as variants that interfere with the molecular efficacy of DNA repair. However, in mul...

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Literature Corpus work: 06344d05-f795-5971-8e44-98d946fc23eb
DOI: 10.1101/2023.12.06.570457

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