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Article

Mcph1, mutated in primary microcephaly, is also crucial for erythropoiesis.

EMBO reports - 1 May 2024

Vial Yoann, Nardelli Jeannette, Bonnard Adeline A, Rousselot Justine, Souyri Michèle, Gressens Pierre, Cavé Hélène, Drunat Séverine

Abstract excerpt

Microcephaly is a common feature in inherited bone marrow failure syndromes, prompting investigations into shared pathways between neurogenesis and hematopoiesis. To understand this association, we studied the role of the microcephaly gene Mcph1 in hematological development. Our research revealed that Mcph1-knockout mice exhibited congenital macrocytic anemia due to impaired terminal erythroid differentiation...

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Source

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Identifiers

PMID: 38605277
DOI: 10.1038/s44319-024-00123-8
PMCID: PMC11094029

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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