Article

Deep deconvolution of the hematopoietic stem cell regulatory microenvironment reveals a high degree of specialization and conservation between mouse and human

2021-07-17

Abstract excerpt

<h4>ABSTRACT</h4> Understanding the regulation of normal and malignant human hematopoiesis requires comprehensive cell atlas of the hematopoietic stem cell (HSC) regulatory microenvironment. Here, we develop a tailored bioinformatic pipeline to integrate public and proprietary single-cell RNA sequencing (scRNA-seq) datasets. As a result, we robustly identify for the first time 14 intermediate cell states and 11 s...

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Literature Corpus work: d9a458c6-ee06-5dde-a3a1-d075d8a8482a
DOI: 10.1101/2021.07.17.452614

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