Article

ECM1 Attenuates Hepatic Fibrosis by Interfering with Mediators of Latent TGF-β1 Activation

2023-12-12

Abstract excerpt

<h4>Objective: </h4> Extracellular Matrix Protein 1 (ECM1) serves as a gatekeeper of hepatic fibrosis by maintaining transforming growth factor-β1 (TGF-β1) in its latent form. ECM1 knockout (KO) causes latent (L) TGF-β1 activation, resulting in hepatic fibrosis with rapid mortality. In chronic liver disease (CLD), ECM1 decreases with increasing CLD severity. We investigate the regulatory role of ECM1 in TGF-β1 bio...

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Literature Corpus work: 3f763b41-9058-5d54-9da0-994cbbd7ddad
DOI: 10.1101/2023.12.12.571289

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