Article

Transient suppression of the ECM1 gatekeeper is essential for HGF/c-MET-driven liver regeneration

2026-06-10

Abstract excerpt

Hepatocyte growth factor (HGF) is a multifunctional cytokine stored in the extracellular matrix as an inactive precursor and is essential for tissue repair. How HGF activity is dynamically regulated during regeneration remains unclear. Here, we identify extracellular matrix protein 1 (ECM1) as a physiological inhibitor of active HGF during liver regeneration. Following 70% partial hepatectomy, active HGF rapidly i...

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Literature Corpus work: 2962b852-b543-5c52-8589-0d6c4584a395
DOI: 10.64898/2026.06.08.730887

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