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Article

TGF-β-induced differentiation into myofibroblasts involves specific regulation of two MKL1 isoforms

1 Jan 2014

Abstract excerpt

Cellular transformation into myofibroblasts is a central physiological process enabling tissue repair. Its deregulation promotes fibrosis and carcinogenesis. TGF-β is the main inducer of the contractile gene program that drives myofibroblast differentiation from various precursor cell types. Crucial regulators of this transcriptional program are serum response factor (SRF) and its cofactor MKL1 (also known as...

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PMID: 24424023
DOI: 10.1242/jcs.142075

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