Article

Balance Between EGF/STAT1 and IFNγ/NRF2 Signaling Controls ECM1 Expression and Determines Hepatic Homeostasis versus Chronic Liver Disease

2024-02-19

Abstract excerpt

In healthy livers, extracellular matrix protein 1 (ECM1) is essential for liver homeostasis by keeping latent transforming growth factor-β (LTGF-β) quiescent. Upon hepatocyte damage, ECM1 is downregulated, facilitating LTGF-β activation and fibrogenesis. However, little is known about how hepatic ECM1 is regulated. Here we found in healthy hepatocytes, EGF/EGFR signaling sustains ECM1 expression through phosphoryl...

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Literature Corpus work: ec0bfd12-341a-5108-8e49-a72fb848fa09
DOI: 10.1101/2024.02.17.580798

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