Article

Characterization of the BRAF interactome identifies BRAF <sup>V600E</sup> <=>TP53 interaction in melanoma

2025-06-25

Abstract excerpt

<h4>ABSTRACT</h4> Melanoma is a highly aggressive and frequently metastatic cancer with its incidence reported to be on the rise. Although most oncogenic drivers in melanoma converge on activation of the RAS>RAF>MEK>ERK MAPK signaling pathway, not all MAPK-activating mutations are recurrently observed in this disease, suggesting a unique functional role for BRAF V600E , which is present in ∼50% of all melanoma c...

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Literature Corpus work: 3f59e396-2209-5778-b55d-16b16bd7c502
DOI: 10.1101/2025.06.20.660711

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