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Article

BRAF: A Two-Faced Janus.

Cells - 27 Nov 2020

Pisapia Pasquale, Pepe Francesco, Iaccarino Antonino, Sgariglia Roberta, Nacchio Mariantonia, Russo Gianluca, Gragnano Gianluca, Malapelle Umberto, Troncone Giancarlo

Abstract excerpt

Gain-of-function of V-Raf Murine Sarcoma Viral Oncogene Homolog B (BRAF) is one of the most frequent oncogenic mutations in numerous cancers, including thyroid papillary carcinoma, melanoma, colon, and lung carcinomas, and to a lesser extent, ovarian and glioblastoma multiforme. This mutation aberrantly activates the mitogen-activated protein (MAP) kinase extracellular signal-regulated kinase (MEK)/extracellular...

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Identifiers

PMID: 33260892
DOI: 10.3390/cells9122549
PMCID: PMC7760616

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