Article
Mutually exclusive genetic interactions and gene essentiality shape the genomic landscape of primary melanoma.
The Journal of pathology - 1 Jan 2023
Birkeälv Sofia, Harland Mark, Matsuyama Larissa Satiko Alcantara Sekimoto, Rashid Mamun, Mehta Ishan, Laye Jonathan P, Haase Kerstin, Mell Tracey, Iyer Vivek, Robles-Espinoza Carla Daniela, McDermott Ultan, van Loo Peter, Kuijjer Marieke L, Possik Patricia A, Maria Engler Silvya Stuchi, Bishop D Timothy, Newton-Bishop Julia, Adams David J
Abstract excerpt
Melanoma is a heterogenous malignancy with an unpredictable clinical course. Most patients who present in the clinic are diagnosed with primary melanoma, yet large-scale sequencing efforts have focused primarily on metastatic disease. In this study we sequence-profiled 524 American Joint Committee on Cancer Stage I-III primary tumours. Our analysis of these data reveals recurrent driver mutations, mutually...
Topics
- Humans
- Mutation
- Melanoma
- Genome
- Genomics
- United Kingdom