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Transgenic mice overexpressing mutant TDP-43 show aberrant splicing of autism associated gene Zmynd11 prior to onset of motor symptoms

2022-12-13

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Mutations in TDP-43 are known to cause Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). TDP-43 binds to and regulates splicing of several RNA including Zmynd11 . Zmynd11 is a transcriptional repressor and a potential E3 ubiquitin ligase family member, known for its role in neuron and muscle differentiation. Mutations in Zmynd11 have been associated with autism with significant developmental...

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Literature Corpus work: 3f1e39b3-cb8e-5df5-a7d6-c72366103171
DOI: 10.1101/2022.12.11.519991

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Transgenic mice overexpressing mutant TDP-43 show aberrant splicing of autism associated gene <i>Zmynd11</i> prior to onset of motor symptoms

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