Article

TDP-43 loss of function drives aberrant splicing in Parkinson’s disease

2025-09-09

Abstract excerpt

<h4>Introductory paragraph</h4> While mRNA splicing dysregulation is a well-established contributor to neurodegeneration in disorders such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), its role in Parkinson’s disease (PD) remains underexplored. Here, we analyse transcriptomic data from >500 post-mortem human brain samples from individuals with and without PD to show that splicing alter...

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Literature Corpus work: 00bb19ae-a50e-595c-af82-b67e8cf40ed3
DOI: 10.1101/2025.09.04.673943

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