Article

FAD mutations suppress brain angiogenesis and neuroprotection by reducing γ-secretase processing and dimerization of VEGFR2

2026-05-15

Abstract excerpt

Efficient cerebrovasculature is vital to neuronal health and cognition and evidence shows that most dementia patients have cerebrovascular abnormalities. Brain vasculature is regulated by Vascular Endothelial Growth Factors (VEGFs) binding VEGF receptor2 (VEGFR2) and stimulating angiogenesis and neuroprotection. Here we show that an ADAM17 cleavage of extracellular VEGFR2 produces the membrane-bound γ-secretase su...

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Literature Corpus work: 3f101b88-bbfc-5602-8603-d76175f163a0
DOI: 10.64898/2026.05.12.724648

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