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Article

Presenilin 1 mutations influence processing and trafficking of the ApoE receptor apoER2.

Neurobiology of aging - 1 Jan 2017

Wang Wei, Moerman-Herzog Andrea M, Slaton Arthur, Barger Steven W

Abstract excerpt

Presenilin (PS)-1 is an intramembrane protease serving as the catalytic component of γ-secretase. Mutations in the PS1 gene are the most common cause of familial Alzheimer's disease (FAD). The low-density lipoprotein (LDL)-receptor family member apoER2 is a γ-secretase substrate that has been associated with AD in several ways, including acting as a receptor for apolipoprotein E (ApoE). ApoER2 is processed by...

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Source

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Identifiers

PMID: 27810638
DOI: 10.1016/j.neurobiolaging.2016.10.005
PMCID: PMC5154819

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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