Article
In Vitro Th Differentiation Protocol.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2016
Sekiya Takashi, Yoshimura Akihiko
Abstract excerpt
CD4(+) T cells play central roles in adaptive immunity, driving appropriate immune responses to invading pathogens of diverse types. Four major CD4(+) T cell subsets, Th1, Th2, Th17, and Treg cells are differentiated from naïve CD4(+) T cells upon ligation of their T cell receptors with antigens, depending on the cytokines they receive. Th1 cells, which are induced by IL-12 and IFN-γ, mediate host defense against...
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