Article

Systematic spatio-temporal mapping reveals divergent cell death pathways in three mouse models of hereditary retinal degeneration

2019-02-19

Abstract excerpt

Calcium (Ca 2+ ) dysregulation has been linked to neuronal cell death, including in hereditary retinal degeneration. Ca 2+ dysregulation is thought to cause rod and cone photoreceptor cell death. Spatial and temporal heterogeneities in retinal disease models have hampered validation of this hypothesis. We examined the role of Ca 2+ in photoreceptor degeneration, assessing the activation pattern of Ca 2+ -depe...

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Literature Corpus work: 3ed48973-d2fa-5415-93c9-6d6bd4326ca7
DOI: 10.1101/554733

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