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Autophagy disruption and mitochondrial stress precede photoreceptor necroptosis in multiple mouse models of inherited retinal disorders

2024-08-02

Abstract excerpt

Inherited retinal diseases (IRDs) are a leading cause of blindness worldwide. One of the greatest barriers to developing treatments for IRDs is the heterogeneity of these disorders, with causative mutations identified in over 280 genes. It is therefore a priority to find therapies applicable to a broad range of genetic causes. To do so requires a greater understanding of the common or overlapping molecular pathway...

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Literature Corpus work
01597ff9-2d17-511f-997c-22d908e7bd22
DOI
10.1101/2024.08.02.606303
Open publication

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Autophagy disruption and mitochondrial stress precede photoreceptor necroptosis in multiple mouse models of inherited retinal disordersDOI 10.1101/2024.08.02.606303
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