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Systematic spatiotemporal mapping reveals divergent cell death pathways in three mouse models of hereditary retinal degeneration

11 Nov 2019

Abstract excerpt

Abstract Calcium (Ca 2+ ) dysregulation has been linked to neuronal cell death, including in hereditary retinal degeneration. Ca 2+ dysregulation is thought to cause rod and cone photoreceptor cell death. Spatial and temporal heterogeneities in retinal disease models have hampered validation of this hypothesis. We examined the role of Ca 2+ in photoreceptor degeneration, assessing the activation pattern of Ca 2+...

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PMID: 31710697
DOI: 10.1002/cne.24807

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