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Inherited retinal degeneration: T-type voltage-gated channels, Na <sup>+</sup> /Ca <sup>2+</sup> -exchanger and calpain-2 promote photoreceptor cell death

2023-07-18

Abstract excerpt

<h4>ABSTRACT</h4> Inherited retinal degeneration (IRD) refers to a group of untreatable blinding diseases characterized by a progressive loss of photoreceptors. IRD pathology is often linked to an excessive activation of cyclic nucleotide-gated channels (CNGC) leading to Na + – and Ca 2+ -influx, subsequent activation of voltage-gated Ca 2+ -channels (VGCC), and further Ca 2+ influx. However, whether and how...

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Literature Corpus work
80a5d348-eb5f-5ec2-8772-2727ee5b35b9
DOI
10.1101/2023.07.16.549200
Open publication

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