Article

Single-cell transcriptomic profiling in inherited retinal degeneration reveals distinct metabolic pathways in rod and cone photoreceptors

2022-08-26

Abstract excerpt

The cellular mechanisms underlying hereditary photoreceptor degeneration are still poorly understood. The aim of this study was to systematically map the transcriptional changes that occur in the degenerating mouse retina at the single cell level. To this end, we employed single cell RNA-sequencing (scRNA-seq) and retinal degeneration-1 ( rd1 ) mice to profile the impact of the disease mutation on the diverse ret...

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Literature Corpus work: 138f8b77-ffd6-56b7-a9c4-b19a76300a32
DOI: 10.1101/2022.08.26.505393

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