Article
Identification of a common non-apoptotic cell death mechanism in hereditary retinal degeneration.
PloS one - 1 Jan 2014
Arango-Gonzalez Blanca, Trifunović Dragana, Sahaboglu Ayse, Kranz Katharina, Michalakis Stylianos, Farinelli Pietro, Koch Susanne, Koch Fred, Cottet Sandra, Janssen-Bienhold Ulrike, Dedek Karin, Biel Martin, Zrenner Eberhart, Euler Thomas, Ekström Per, Ueffing Marius, Paquet-Durand François
Abstract excerpt
Cell death in neurodegenerative diseases is often thought to be governed by apoptosis; however, an increasing body of evidence suggests the involvement of alternative cell death mechanisms in neuronal degeneration. We studied retinal neurodegeneration using 10 different animal models, covering all major groups of hereditary human blindness (rd1, rd2, rd10, Cngb1 KO, Rho KO, S334ter, P23H, Cnga3 KO, cpfl1, Rpe65...
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