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Article

TP53 and KMT2D mutations associated with worse prognosis in peripheral T-cell lymphomas.

Cancer medicine - 1 Jul 2024

Wang Lingling, Yang Lei, Guan Fangshu, Chen Jing, Cheng Yuexin, Miao Yuqing, He Jingsong, Cai Zhen, Huang He, Zhao Yi

Abstract excerpt

There are limited studies on mutation profiling for Peripheral T-cell lymphomas (PTCL) in the Chinese population. We retrospectively analyzed the clinical and genetic landscape of 66 newly diagnosed Chinese patients. Targeted next-generation sequencing (NGS) was performed for tissues from these patients. At least one mutation was detected in 60 (90.9%) patients, with a median number of 3 (0-7) mutations, and 32...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39041683
DOI: 10.1002/cam4.70027
PMCID: PMC11264255

Genes

KMT2D
TP53
DNMT3A
IDH2
RHOA
STAT3
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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