Article
Molecular heterogeneity in peripheral T-cell lymphoma, not otherwise specified revealed by comprehensive genetic profiling.
Leukemia - 1 Dec 2019
Watatani Yosaku, Sato Yasuharu, Miyoshi Hiroaki, Sakamoto Kana, Nishida Kenji, Gion Yuka, Nagata Yasunobu, Shiraishi Yuichi, Chiba Kenichi, Tanaka Hiroko, Zhao Lanying, Ochi Yotaro, Takeuchi Yasuhide, Takeda June, Ueno Hiroo, Kogure Yasunori, Shiozawa Yusuke, Kakiuchi Nobuyuki, Yoshizato Tetsuichi, Nakagawa Masahiro M, Nanya Yasuhito, Yoshida Kenichi, Makishima Hideki, Sanada Masashi, Sakata-Yanagimoto Mamiko, Chiba Shigeru, Matsuoka Ryota, Noguchi Masayuki, Hiramoto Nobuhiro, Ishikawa Takayuki, Kitagawa Junichi, Nakamura Nobuhiko, Tsurumi Hisashi, Miyazaki Tatsuhiko, Kito Yusuke, Miyano Satoru, Shimoda Kazuya, Takeuchi Kengo, Ohshima Koichi, Yoshino Tadashi, Ogawa Seishi, Kataoka Keisuke
Abstract excerpt
Peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS) is a diagnosis of exclusion, being the most common entity in mature T-cell neoplasms, and its molecular pathogenesis remains significantly understudied. Here, combining whole-exome and targeted-capture sequencing, gene-expression profiling, and immunohistochemical analysis of tumor samples from 133 cases, we have delineated the entire landscape of...
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