Article
Tumor mutation burden involving epigenetic regulatory genes and the RhoA GTPase predicts overall survival in nodal mature T-cell lymphomas.
Clinical epigenetics - 19 Dec 2022
de Pádua Covas Lage Luís Alberto, Culler Hebert Fabrício, Barreto Guilherme Carneiro, Reichert Cadiele Oliana, Levy Débora, de Oliveira Costa Renata, Rocha Vanderson, Pereira Juliana
Abstract excerpt
Nodal mature T-cell lymphomas (nMTCL) comprises a heterogeneous group of rare malignancies with aggressive biological behavior and poor prognosis. Epigenetic phenomena, including mutations in genes that control DNA methylation and histone deacetylation, in addition to inactivating mutations in the RhoA GTPase, play a central role in its pathogenesis and constitute potential new targets for therapeutic...
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