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Article

An <i>ex vivo</i> functional biomarker of treatment response in pediatric low-grade glioma

2025-09-12

Abstract excerpt

<h4>Background</h4> Children with subtotally resected pediatric low-grade glioma (pLGG) often face multiple lines of treatment, which are seldom capable of eliminating the entire tumor. Genomics-based biomarkers are often used to select targeted therapies, but this paradigm only yields overall response rates of ∼50% optimally. Functional precision medicine (FPM), where patient-specific therapeutic efficacy is eva...

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Literature Corpus work
3eba583c-738a-58a1-9a9a-5aee96913acf
DOI
10.1101/2025.09.11.25333944
Open publication

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An <i>ex vivo</i> functional biomarker of treatment response in pediatric low-grade gliomaDOI 10.1101/2025.09.11.25333944
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