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Capturing a crucial ‘disorder-to-order transition’ at the heart of the coronavirus molecular pathology – triggered by highly persistent, interchangeable salt-bridges

2021-12-29

Abstract excerpt

The COVID-19 origin debate has greatly been influenced by Genome comparison studies of late, revealing the seemingly sudden emergence of the Furin-Like Cleavage Site at the S1/S2 junction of the SARS-CoV-2 Spike (FLCS Spike ) containing its 681 PRRAR 685 motif, absent in other related respiratory viruses. Being the rate-limiting (i.e., the slowest) step, the host Furin cleavage is instrumental in the abrupt inc...

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Literature Corpus work: 3e958f91-c851-55dd-872f-002fc709ad4c
DOI: 10.1101/2021.12.29.474439

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