Article

BPIFB1 loss alters airway mucus properties and diminishes mucociliary clearance

2020-06-18

Abstract excerpt

<h4>ABSTRACT</h4> Airway mucociliary clearance (MCC) is required for host defense and often diminished in chronic lung diseases. Effective clearance depends upon coordinated actions of the airway epithelium and a mobile mucus layer. Dysregulation of the primary secreted airway mucin proteins, MUC5B and MUC5AC, is associated with a reduction in the rate of MCC; however, how other secreted proteins impact the integ...

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Identifiers and source

Literature Corpus work: 38390676-aae7-51c5-b588-23e432225cbd
DOI: 10.1101/2020.06.17.155846

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