Article

An innate immune circuit involving the lectin pathway, complement and lung epithelial cells enforce barrier immunity to inhaled fungal disease

2026-06-16

Abstract excerpt

<h4>SUMMARY</h4> The lung mucosal barrier thwarts many inhaled pathogens, including Coccidioides , the causative agent of Valley Fever. Because the earliest stages of pathogen recognition in the lung remain obscure, we investigated the initial events of barrier immunity in a murine model involving inhalation of Coccidioides sp. arthroconidia. Neutrophils accumulated rapidly, within 24 hours, near fungal spores...

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Literature Corpus work: 3033dca4-0d82-5371-8bf1-5917dc7edb95
DOI: 10.64898/2026.06.15.732416

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