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Ex vivo HSC expansion challenges the paradigm of unidirectional human hematopoiesis

14 Jun 2019

Abstract excerpt

Understanding mechanisms that determine the behavior of human hematopoietic stem cells (HSCs) is essential for developing novel strategies to expand ex vivo the number of fully functional HSCs. In this review, we focus on the complex interplay between intrinsic mechanisms regulated by transcriptional and mitochondrial networks and extrinsic signals imposed by the bone marrow microenvironment, which in concert...

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PMID: 31199002
DOI: 10.1111/nyas.14133

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