Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Direct Oral Anticoagulant Protein Targets and Risk of Cerebral Venous Thrombosis: A Mendelian Randomization Study.

Neurology - 14 Apr 2026

Daghlas Iyas, Perez-Alcantara Marta, Gill Dipender

Abstract excerpt

OBJECTIVES: It is uncertain whether the protein targets of direct oral anticoagulants (DOACs) causally influence cerebral venous thrombosis (CVT) risk. We used Mendelian randomization (MR) to examine the association between genetically proxied levels of DOAC protein targets and CVT risk. METHODS: We identified genetic proxies for the protein targets of established and emerging DOACs: circulating thrombin,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Administration, Oral
Share to Anticoagulants
Share to Factor Xa

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Factor XI

Share to Intracranial Thrombosis

Share to Mendelian Randomization Analysis

Share to Thrombin

Share to Venous Thrombosis

Source

Identifiers

PMID: 41785432
DOI: 10.1212/WNL.0000000000214759

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Direct Oral Anticoagulant Protein Targets and Risk of Cerebral Venous Thrombosis: A Mendelian Randomization Study.PMID 41785432Read ↗

Genetically Proxied Inhibition of Coagulation Factors and Risk of Cardiovascular Disease: A Mendelian Randomization Study.Semantic proximity Read ↗

Genetic assessment of efficacy and safety profiles of coagulation cascade proteins identifies Factors II and XI as actionable anticoagulant targetsSemantic proximity Read ↗

Gene-Gene Interaction Between Factor-XI and ABO Genes in Cerebral Venous Thrombosis: The BEAST Study.Semantic proximity Read ↗

Application of Human Genetics to Prioritize Coagulation Cascade Protein Targets for Ischemic Stroke PreventionSemantic proximity Read ↗

Non-genetic and genetic risk factors for adult cerebral venous thrombosis.Semantic proximity Read ↗

Genetic Susceptibility to Adult Cerebral Venous Thrombosis: An Updated Meta-Analysis of Candidate Gene Studies.Semantic proximity Read ↗

Next-generation DNA sequencing to identify novel genetic risk factors for cerebral vein thrombosis.Semantic proximity Read ↗

A Mendelian randomization of γ' and total fibrinogen levels in relation to venous thromboembolism and ischemic stroke.Semantic proximity Read ↗

Leveraging Mendelian randomization to inform drug discovery and development for ischemic strokeSemantic proximity Read ↗

Identification of potential biomarkers and therapeutic targets for cerebral venous thrombosis.Semantic proximity Read ↗

Genes associated with adult cerebral venous thrombosis.Semantic proximity Read ↗

Haplotypes of TAFI gene and the risk of cerebral venous thrombosis--a case-control study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.