Article
Cell-Cycle-Targeting MicroRNAs as Therapeutic Tools against Refractory Cancers.
Cancer cell - 10 Apr 2017
Hydbring Per, Wang Yinan, Fassl Anne, Li Xiaoting, Matia Veronica, Otto Tobias, Choi Yoon Jong, Sweeney Katharine E, Suski Jan M, Yin Hao, Bogorad Roman L, Goel Shom, Yuzugullu Haluk, Kauffman Kevin J, Yang Junghoon, Jin Chong, Li Yingxiang, Floris Davide, Swanson Richard, Ng Kimmie, Sicinska Ewa, Anders Lars, Zhao Jean J, Polyak Kornelia, Anderson Daniel G, Li Cheng, Sicinski Piotr
Abstract excerpt
Cyclins and cyclin-dependent kinases (CDKs) are hyperactivated in numerous human tumors. To identify means of interfering with cyclins/CDKs, we performed nine genome-wide screens for human microRNAs (miRNAs) directly regulating cell-cycle proteins. We uncovered a distinct class of miRNAs that target nearly all cyclins/CDKs, which are very effective in inhibiting cancer cell proliferation. By profiling the...
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